高辉简介
姓名
高辉
性别
出生年月
1973年12月
学历学位
博士 博士
职 称 教授
所属学院
化学化工学院 是否博硕导 硕导
联系电话 022-60214259
E_mail
Hgao@tjut.edu.cn
所属学科 100701 药物化学
081700 化学工程与技术
研究方向
 生物医用高分子合成及其性能研究,抗癌药物、蛋白质、肽类药物等的缓、控释体系,环境响应性智能给药系统
人才称号
教育部新世纪优秀人才支持计划人选 ;
学术兼职
European Journal of Pharmaceutics and Biopharmaceutics审稿人
讲授课程
药学专业英语,药事管理学,药用高分子材料
主要科研项目及代表性成果(包括鉴定项目、论文、专著、获奖、专利等):
  

项目:

1. 国家自然科学基金项目:基于beta-环糊精的反相高分子胶束的构建及其在肽类药物传输中的应用(21374079),2014.01-2017.12,83万,主持;

2. 国家自然科学基金项目:含 beta-环糊精高分子的合成、反相胶束的构建及其在肽类药物控制释放中的应用(21244004),2013.01-2013.12,10万,主持;

3. 国家自然科学基金项目:含多氢键给体的高分子的合成及其作为基因载体的性能研究(21074092),2011.01-2013.12, 35万,主持;

4. 2012年入选天津市高校“中青年骨干创新人才培养计划”2012年12月—2015年11月,45万,主持

5. 天津市自然科学基金:侧链降解型聚阳离子基因载体的合成及其性能研究(10JCYBJC26800),2010.10 - 2013.09,10万,主持;

6. 973计划前期专项:新型生物降解高分子纳米材料的合成及其环境响应性能(2009CB626612),2009.04-11.08,55万元,与南开大学马建标教授合作项目;是天津理工大学方负责人(结题);

7. 天津市高等学校科技发展基金计划项目:羧基聚甲基丙烯酸甘油酯的合成及对阿霉素的控制释放20090505,2009.12-2012.12,3万元,主持(结题)。

8. 教育部新世纪优秀人才支持计划,2012.01-2014.12,50万,主持;

论文:

1.       H Gao, H Takemoto, Q  Chen, M Naito, H Uchida, X  Liu, K Miyata,* K Kataoka,* Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity,Chem. Commun. 2015, 51, 3158-3161  (IF=6.72).

2.       Gu W-X, Li Q-L, Lu H, Fang L, Chen Q, Y-W Yang,* Hui Gao*, Construction of stable polymeric vesicles based on azobenzene and beta-cyclodextrin grafted poly(glycerol methacrylate)s for potential applications in colon-specific drug delivery, Chem. Commun. 2015, 51, 4715-4718 (IF=6.72).

3.      W-X Gu, M Zhu, N Song, X Du, Y-W Yang, H. Gao, * Reverse Micelles Based on Biocompatible β-Cyclodextrin Conjugated Polyethylene Glycol Block Polylactide for Protein Delivery. J. Mater. Chem. B, 2015, 3, 316–322.

4.      X Du, N. Song, Y-W-Yang, G Wu, J Ma, H Gao.* Reverse micelles based on β-cyclodextrin-incorporated amphiphilic polyurethane copolymers for protein delivery, 2014, Polym. Chem. 5300-5309(IF=5.37).

5.      W-X Gu, Y-W Yang, J Wen, H Lu, H Gao * Construction of Reverse Vesicles from Pseudo-Graft Poly(Glycerol Methacrylate)s via Cyclodextrin-Cholesterol Interaction. Polym. Chem. 2014, 5, 6344–6349. (IF=5.37).

6.      Q-L Li, L-ZWang, X-.Qiu, Y-L Sun, P-XWang, Y Liu, F Li, A-D Qi, H Gao,* Y-W Yang,* Stimuli-responsive biocompatible nanovalve based on β-cyclodextrin modified poly(glycidyl methacrylate), 2014, Polym. Chem.  2014, 5, 3389-3395 (IF=5.37).

7.      Q-L Li, W Gu, H. Gao, * Yang, Y.-W.* Self-Assembly and Applications of Poly(Glycidyl Methacrylate)s and Their Derivatives. Chem. Commun. 2014, 50, 13201–13215. (IF: 6.718 ) .

8.      L Wang, Y.-W. Yang, M. Zhu, G Qiu, G Wu, H Gao.* β-Cyclodextrin-conjugated amino poly(glycerol methacrylate)s for efficient insulin delivery, 2014, RSC Adv., 2014,4, 6478-6485 (IF=3.70).

9.      Q-L Li, Y Sun, Y -L Sun, J Wen, Y Zhou, Q Bing, L Isaacs, Y Jin, H Gao, * Y-W Yang,* Mesoporous Silica Nanoparticles Coated by Layer-by-Layer Self-Assembly Using Cucurbit[7]uril for in Vitro and in Vivo Anticancer Drug Release. Chem. Mater. 2014, 26, 6418–6431. (IF= 8.535).

10.  D-E Liu, H Han, H Lu, G Wu, Y Wang, J Ma, Hui Gao*, Synthesis of amphiphilic polyaspartamide derivatives and construction of reverse mice, RSC Adv., 2014,4, 37130-37137 (IF=3.70).

11.  H Han, D -E Liu, H  Lu, W-X Gu, Hui Gao*, Construction of micelles based on biocompatible pseudo-graft polymers via b-cyclodextrin/cholesterol interaction for protein delivery, RSC Adv., 2014,4, 40882-40891 (IF=3.70).

12.  Y Sun, Y.-L. Sun, L Wang, J. Ma, Y.-W. Yang,* H Gao.* Nanoassembles constructed from mesoporous silica nanoparticles and surface-coated multilayer polyelectrolytes for controlled drug delivery, 2014, Micropor. Mesopor. Mater. 185, 245-253(IF=3.37)..

13.  Z Liang, M Zhu, Y.-W. Yang, Gao, H.* Antimicrobial activities of polymeric quaternary ammonium salts from poly(glycidyl methacrylate)s, 2014, Polym. Adv. Technol. 25, 117-122(IF=1.64)..

14.  H Gao,* Z Liang, X Wu, C Li, Y-W Yang, G. Wu, J Ma, Quaternized poly(Glycerol Methacrylate)s for enhanced pDNA delivery, 2013, J. Controlled Release 172, e104-e105(IF=7.26);

15.  C Li, Y-W Yang, Z-X Liang, G-L Wu, and H Gao* Post-modification poly(glycidyl methacrylate)s with alkyl amine and isothiocyanate for effective pDNA delivery, 2013, Polymer Chemistry, 4: 4366-4374 (IF=5.37);

16.  Z Liang, Xi Wu, Y-W Yang, C Li, G Wu, and H Gao,* Quaternized amino poly(glycerol-methacrylate)s for enhanced pDNA deliver, 2013, Polymer Chemistry, 4: 3514-3523 (IF=5.3);

17.  Y Sun, H Gao,* Y-W Yang, A Wang, G Wu, Y Wang, Yu Fan, J Ma, Layer-by-layer supramolecular assemblies based on linear and star-shaped poly(glycerol methacrylate)s for doxorubicin delivery. 2013, Journal of Biomedical Materials Research Part A, 101A: 2164-2173 (IF=2.6);

18.  A Wang, H Gao,* Y Sun, Yu-long Sun, Y-W Yang, G Wu , Y Wang , Y Fan, J Ma, *Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery, 2013, International Journal of Pharmaceutics, 441: 30-39 (IF=3.2);

19.  W Gu, Y Ma, C Zhu, B Chen, J Ma, H Gao,* Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin, 2012, European Journal of Pharmaceutical Sciences 47 (3): 556-563(IF=3.2);

20.  H Gao, M Elsabahy, EV Giger, DK Li, RE Prud’homme, and JC Leroux, Self assembling properties of aminated poly(glycerol methacrylate)s, Journal of controlled release 152: e142-143. (IF=5.7)

21.  Y N Ma, H Gao,* W X Gu, Y W Yang, Y N Wang, Y G Fan, G L Wu,  and J B Ma, Carboxylated poly(glycerol methacrylate)s for doxorubicin delivery, Eur J Pharm Sci, 2012, 45: 65-72. (IDS Number: 892FL, IF=3.3);

22.  X Y Lu, H Gao, * C Li, Y W Yang, Y N Wang, Y G Fan, G L Wu, and J B Ma. Polyelectrolyte complex nanoparticles of amino poly(glycerol methacrylate)s and insulin, Int J Pharm, 2012, 423: 195-201. (IF=3.6);

23.  H Gao, Lu X Y, Y N Ma, Y W Yang, J F Li, G L Wu, Y N Wang, Y G Fan, and Ma J B*. Amino poly(glycerol methacrylate)s for oligonucleic acid delivery with enhanced transfection efficiency and low cytotoxicity, Soft Matter, 2011, 7: 9239-9247. (IDS Number: 822YE , IF=4.6);

24.  H Gao,* Y N Ma, X Y Lu, Y R Liang, B Q Chen, and J B Ma. PH-responsive nano-assemblies of amino poly(glycerol methacrylate), Eur Pol J, 2011, 47:1232-1239(IDS Number: 776GX,  IF=2.9);

25.  H G Fu, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma. Preparation and tunable temperature-sensitivity of biodegradable polyurethane nanoassemblies from diisocyanate and poly(ethylene Glycol), Soft Matter, 2011, 7: 3546-3552(IDS Number: 738XZ, IF=4.6);

26.  X K Sun, H Gao,* G L Wu, Y N Wang, Y G Fan, and J B Ma. Biodegradable and temperature-responsive polyurethanes for adriamycin delivery, Int J Pharm, 2011,412:52-58(IDS Number: 793EH, IF=3.0); 

27.  H. Gao, M. Elsabahy, E.V. Giger, D.K. Li, R.E. Prud’homme, J.C. Leroux, Aminated linear and star-shape poly(glycerol methacrylate)s: synthesis and self-assembling properties, Biomacromolecules, 2010, 11: 889-895.(IDS Number: 581WW, IF=5.8); 

28.  J. Leblond,; H. Gao, A. Petitjean, Leroux, J.C. Leroux, pH-Responsive molecular tweezers, J Am Chem Soc, 2010, 132:8544-8545. (IDS Number:, IF=8.6);

29.  H. Gao, M.-C. Jones, J. Chen, Y.R. Liang, R. E. Prud’homme, J.-C. Leroux, Hydrophilic nanoreservoirs embedded into polymeric nanoparticles - An approach to compatibilize polar molecules with hydrophobic matrices. Chem Mater, 2008; 20: 4191–4193. (IDS Number: 321BM, IF=8.5); 

30.  H. Gao, M.-C. Jones, J. Chen, R. E. Prud’homme, J.-C. Leroux, Core cross-linked reverse polymeric micelles. Chem Mater, 2008; 20: 3063–3067. (IDS Number: 297NM, IF=8.5); 

31.  M.-C. Jones, H. Gao, J.-C. Leroux, Reverse polymeric micelles for pharmaceutical applications. J. Controlled release, 2008;132:208-215. (IDS Number: 386SL, IF=7.3);

32.  H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Ethylenediamino bridged bis(β-cyclodextrin)/ poly(DL-lactic-co-glycolic acid) nanoparticles prepared by modified double emulsion method: effect of polyvinyl alcohol on nanoparticle properties. J Appl Polym Sci, 2008; 107: 571–576. (IDS Number: 229RP, IF=1.2);

33.  H. Gao, M.-C. Jones, P. Tewari, M. Ranger, J.-C. Leroux, Star-Shaped alkylated poly (glycerol methacrylate) reverse micelles: synthesis and evaluation of their solubilizing properties in dichloromethane. J Polym Sci Part A: Polym Chem,  2007; 45:2425-2435. (IDS Number: 173SZ, IF=4.0);

34.   H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactide-co-glycolide) on amino cyclodextrins and their nanoparticles as protein delivery system. J Biomed Mater Res Pt A, 2007; 80A:111-122. (IDS Number: 114PN, IF=2.8);

35.  H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Conjugates of poly(DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(beta-cyclodextrin)s and their nanoparticles as protein delivery systems. J control release, 2006; 112:301-311. (IDS Number: 057NA, IF=7.3); 

36.  H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Interactions of some modified mono- and bis-beta-cyclodextrins with bovine serum albumin. Bioorgan & Med Chem, 2006; 14:131-137. (IDS Number: 989YB, IF=2.8);

37.  H. Gao, Y.-N. Wang, Y.-G. Fan, J.-B. Ma. Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl) amino-6-deoxy)- β -cyclodextrin and its properties as the new carrier of protein delivery system. J control release, 2005; 107:158-173. (IDS Number: 970YW, IF=7.3)

专著:

1. 功能高分子材料,马建标主编,之第九章医用高分子材料, 第二版:化学工业出版社,2010年. 

专利:

1.高辉; 孙现科; 马建标。具有pH响应性的生物降解聚氨酯材料的制备方法,ZL201010511225.5

2.高辉; 顾文星; 马亚男; 陆学友; 马建标。一种具有PH响应性聚甲基丙烯酸甘油酯的制备方法,ZL201110282730.1

3.高辉;朱明冉。一种基于油相的两亲性高分子反相微乳的制备方法,201310454392.4

4.高辉; 顾文星; 王立志;郭盼。一种准嵌段共聚物反相高分子胶束的制备方法,201310420819.9

获奖:

1马建标、王亦农、王小红、高辉、范云鸽,天然生物高分子的修饰及其生物医学性能(2010ZR-3-006)天津市自然科学三等奖(2010年);

 

指导学生获得

1)第二届“天津市大学生创新、创业奖学金”顾文星获得“创新奖学金”优秀奖。

2)第十二届“挑战杯”全国大学生课外学术科技作品竞赛三等奖,天津市大学生课外学术科技作品竞赛特等奖:高分子的pH响应性能及其对抗癌药物的控制释放。人员:顾文星,朱楚宇、许祥、宋婧怡、王新雷

3)第八届中国青少年科技创新奖 顾文星

 
 
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